StemFit Active - WellMed Global Miami -

A synergistic combination of live functional foods that includes Norweigan incubated fertilized Young Tissue Extract, plant minerals, antioxidants and glyconutrients that have the ability to mobilize the body into an enhanced state for healing, repair and balance.

Benefits:

Increase energy and endurance

Improve focus, attention and concentration

Improve sleep for better recovery

Repair damaged cells

Naturally balance hormones

Faster recovery between workouts or competition

Proven stress reduction for athletes

Prolong peak athletic performance

Balance blood sugar

Reduce pain and inflammation

Information:

The Young Tissue Extract from incubated fertilized hen eggs in stemFit Active™ contains signaling peptides that activate and direct adult stem cells to heal and repair. These special proteins fortify the body against degeneration, raise the production of the youth hormone DHEA and have a profound effect on lowering excessive cortisol levels. These combined effects dramatically increase the recovery rate after physical exercise and sports participation.

With aging and high stress, the level of these signal peptides declines. Not found in any other food sources; they are abundant in our Young Tissue Extract. These signal peptides turn on your DNA switches for health and turn off your DNA switches of accelerated degeneration of your body’s cells. Being able to perform better in sports activities and fitness training, it is necessary to keep a high level of these signal peptides.

Athletes at every level of performance put high demands on their metabolism. stemFit Active™ contains EGCG, a super antioxidant that helps mediate oxidative stress. It enhances metabolism, helps balance glucose levels, increases fat oxidation, and aids in weight management.

The body demands minerals for every cellular function. stemFit Active™ contains a plant-sourced Marine Mineral Complex that is up to 97% absorb- able. It gets the minerals to the cells in the quantity and form that is optimal for utilization. These minerals have been shown in clinical studies to reverse bone loss within a year especially when incorporated with load-bearing sports such as basketball, volleyball, jogging, and soccer.

DOWNLOAD stemFit BROCHURE CLICK HERE

DOWNLOAD stemFit SCIENCE DOCUMENT CLICK HERE

Ingredients:

Authentic incubated fertilized avian egg extract from Norway, Marine Mineral Complex, Shark Cartilage, Glyconutrient, Phytonutrient

Recommendations:

As a dietary supplement, take 2-4 capsules a day or as directed by your health care practitioner.

DOWNLOAD stemFit RECOMMENDATIONS CLICK HERE


http://www.clarosupply.com/StemFit-Active-p/med0163.htm

La Ciencia de la Renovación de las Celulas Madres.

Únete a nosotros y aprende acerca de nuestra “Tecnología Patentada” y conoce a nuestro renombrado científico, reconocido internacionalmente.

Prof. Dr. Luis Romero - Asesor Científico de Wellmed Global

Aplicación anti-envejecimiento de avanzada Tecnología de Factores de Crecimiento introduciendo un Nuevo paradigma de la ciencia y la oportunidad para accederla cada uno de nosotros
Aprende la ciencia de la renovación de los factores de crecimiento que crean en el cuerpo las moléculas de señalamiento que poderosamente dirigirán la “Orquesta” para que se ejecuten las secuencias para la regeneración celular, cura de las heridas y cualquier otro requerimiento para reparar LESIONES … “de dentro hacia fuera”

Próxima Presentación:
Jueves 16 de JULIO de 2015, 
Lugar: 8333 NW - 53rd. Street Suite 402 
(4to. Piso)
DORAL, FL 33166
¡NO SE LA PIERDA!

En www.mywellmed.com/clarosupply encontrara mas informacion acerca de esta fabulosa tecnologia que FUNCIONA.

GFt VRS Vaginal Rejuvenation System. -WellMedGlobal / Clarosupply -

Many women struggle with what is known as "the silent condition." It strikes the healthiest of women leading up to, and during peri-menopause, menopause, and post-menopause. 

The symptoms include dryness, irritation, decreased sexual pleasure and other maladies. VRS is a breakthrough, hormone-free solution that is giving many women their sex lives back! Benefits: -Relieves vaginal dryness and soothes irritation -Improves elasticity, tightens and firms the vaginal walls -Enhances female sexual arousal and intercourse -Rejuvenates vaginal function utilizing GFt Despite the high number of women experiencing symptoms related to vaginal dryness, it is still a silent condition that many women feel embarrassed to share with their partners, friends and even doctors.

Vaginal dryness is a common symptom experienced during the peri-menopausal and postmenopausal years. Although inadequate vaginal lubrication can occur at any age, vaginal dryness is a hallmark sign of vaginal atrophy (atrophic vaginitis)- the thinning and inflammation of the vaginal walls due to a decline in estrogen. Along with vaginal dryness, women may also experience itching and stinging around the vaginal opening, and in the lower third of the vagina. VRS is a breakthrough solution for vaginal rejuvenation. Through Growth Factor (GFt) technology, the VRS serum serves as part of the body's natural lubrication, which consists of thick fluid that is deposited to the contact the walls encircling the vagina. VRS rejuvenates the vagina by helping to restore the body's natural vaginal functions. It strengthens the interior vaginal walls, creating a tightening effect, thus allowing more sensation and youthful resilience to a very important part of a woman's body. This is a non-hormonal treatment.

Benefits:
Relieves vaginal dryness and soothes irritation
Improves elasticity, tightens and firms the vaginal walls
Enhances female sexual arousal and intercourse
Rejuvenates vaginal function utilizing Growth Factor (GF) technology

Box contains (3) 4.0 mL tubes

Information:
Despite the high number of women experiencing symptoms related to vaginal dryness, it is still a silent condition that many women feel embarrassed to share with their partners, friends, and even doctors. Vaginal dryness is a common symptom experienced during the perimenopausal and postmenopausal years. Although inadequate vaginal lubrication can occur at any age, vaginal dryness is a hallmark sign of vaginal atrophy (atrophic vaginitis) – the thinning and inflammation of the vaginal walls due to a decline in estrogen. Along with vaginal dryness, women may also experience itching and stinging around the vaginal opening, and in the lower third of the vagina.

VRS is a breakthrough solution for vaginal rejuvenation. Through Growth Factor (GFt) technology, the VRS serum serves as part of the body’s natural lubrication, which consists of thick fluid that is deposited to contact the walls encircling the vagina. VRS rejuvenates the vagina by helping to restore the body’s natural vaginal functions. Further, the VRS product can help women achieve heightened vaginal sensations. VRS is formulated and designed to hydrate the interior vaginal walls, and create a tightening effect, thus allowing more sensation and youthful resilience to a very important part of a woman’s body, while being a non-hormonal treatment.

Box contains (3) 4.0 mL tubes

Ingredients:
Human Fibroblast Conditioned Media, Water (Aqua), Glycerin, Simmondsia Chinensis (Jojoba) Seed Oil, Xanthum Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Polysorbate 60, Rosemarinus Officinalis (Rosemary) Leaf Oil, Lactic Acid, Chlorphenesin

Directions:
Each VRS™ tube contains a specified dose of the serum to generously supply the affected vaginal area with rejuvenating serum.
Wash hands thoroughly.
Ensure that the vaginal area is clean.
Remove the tube from the protective wrapper.
Hold tube firmly at the thick end and shake down to ensure that the contents are at the tip of the tube ready to be dispersed.
Open tube by gently twisting off the flattened tab of the tube and discard the tab.
Gently insert the narrow open end of the tube into the vagina and SLOWLY squeeze at the thick end of the tube to release
the contents into the vaginal cavity. (If you squeeze too hard or too fast, the contents of the tube might not be absorbed quickly enough and could cause dripping.)
Remove the tube from vagina and discard.
Note: If you find that by using the entire content of the tube causes dripping, use only half of a tube at a time and refrigerate the remainder by placing the tube in a clean, sealed, plastic storage bag. Use the remaining half of tube within 3 days.
For Optimal Results:
For best results, dispense the VRS™ while lying down, or just before going to bed at night. This will help the product better absorb into the vaginal tissue, and prevent excess dripping. However, VRS™ can be used at any time depending
on preference.
VRS™ can also be used prior to sexual relations to lubricate and enhance the experience. It is suggested you wait about
10-15 minutes after application so that the serum can be absorbed before sexual intercourse. This product is safe in case of oral contact.
VRS™ can also be used prior to sexual relations to lubricate and enhance the experience.
If it is painful or uncomfortable to insert the VRS™ applicator tube into the vagina, to help alleviate some discomfort, using
clean fingertips, dispense a small amount of the VRS™ serum to lubricate the area prior to inserting the tube. This will help and it will also ensure the VRS™ serum is coating the outer vaginal area and it will also help increase restoration and repair to that area.
Do not apply during the menstrual cycle. Wait until after for best results.
Women who are in the early stages of perimenopause may find that using the VRS™ once a month will help them maintain optimal health and comfort as their body starts to transition into the last phases of fertility. Women who are in menopause may require the use of VRS™ three or more times per month. Women who are in full menopause, or are postmenopausal,may like to use the VRS™ weekly to help restore the cellular health of the vaginal area. It is all dependent on the needs of the individual.
VRS™ is safe, natural and effective. It has none of the side effects or dangers of hormones, does not require a
prescription, and has been shown in double-blind studies to be more effective than hormone replacement therapy or topical lubricants, as measured in lubrication, secretions, mucosal thickness, firming of vaginal walls, as well as, increased
response and sensitivity.

DERMATOLOGIC THERAPY - Endogenous growth factors as cosmeceuticals.

DERMATOLOGIC THERAPY  

Endogenous growth factors as cosmeceuticals

RAHUL  C. MEHTA * & RICHARD  E. F ITZPATRICK †
* Research and Development, SkinMedica, Inc., Carlsbad, California and  † La Jolla Cosmetic Surgery Center, La Jolla, California.

ABSTRACT:

Growth factors play an important role in reversing the effects of skin aging mediated by chronological and environmental factors. Excessive oxidation of intra- and extracellular components result in breakdown of collagen and elastin network in the dermis and produce the effect of facial aging. Topical application of human growth factors in multiple clinical studies has been shown to reduce the signs and symptoms of skin aging, including statically significant reduction in fine lines and wrinkles and increase in dermal collagen synthesis. More double-blind and controlled studies are needed to confirm the preliminary clinical effects of growth factor products, and more controls on product quality and stability need to be established.

Introduction:

Aging of the skin is mediated by a combination of the effects of time (intrinsic aging) and environmental factors (extrinsic aging) on cellular and extracellular infrastructure. These are two independent, clinically and biologically distinct, processes that affect the skin structure and function simultaneously (1,2). Growing evidence now suggests that the two aging processes have converging biochemical and molecular pathways that lead to photoaging of skin (3,4). The common mechanisms of the two aging processes may provide several unique opportunities to develop new antiaging therapies. Recent advances in understanding the role of endogenous growth factors in the aging process provide one such opportunity to develop novel antiaging cosmeceutic products. 


Intrinsic and extrinsic aging of skin:
 
Intrinsic or sun-protected aging of skin is mediated by the “biologic clock” that affects the skin in the same manner as it affects the internal organs, i.e., by slow, irreversible tissue degeneration. Telomere shortening combined with metabolic oxidative damage is believed to play a major role in the intrinsic aging process (5). Intrinsic aging affects everyone at different rates based on genetic factors (6). Intrinsically aged skin is thinner, more evenly pigmented, shows higher laxity, and less fold accentuation as compared to photoaged skin. Extrinsic aging is mediated by environmental factors including exposure of skin to solar UV radiation and environmental pollutants. Photoaged skin usually shows coarseness, wrinkling, sallow discoloration, telangiectasia, elastosis, irregular pigmentation, and a variety of benign, premalignant and malignant neoplasm (3). Intrinsic and extrinsic aging are cumulative processes that occur simultaneously, and over time result in photoaging. Histologic evaluations show that sun-protected skin contains a lower number of fibroblasts, flat epidermal–dermal interface with loss of the dermal papillae, elevated levels of partially degraded collagen, and irregularly thickened, fragmented, and disorganized elastic tissue network (7,8). It also shows a reduction in total elastin content and ability to synthesize type I procollagen as compared to young skin (8,9). Photoaged skin shows a statistically significant decrease (20%) in total collagen as compared to sun-protected skin 

FIG. 1. Biochemical pathways of intrinsic and extrinsic aging leading to the symptoms of photoaging.

(10–12). Photoaged skin also shows marked elastosis with thickened, tangled, and amorphous elastic structures containing fragments of elastin and collagen that replace degenerating collagenous meshwork (8,13–17). The mean epidermal thickness appears to decrease with age in either sunprotected or photoaged skin (18,19).

Biochemical pathways of skin aging:
 
Extensive research in the area of photoaging over the past decade has resulted in an improved understanding of the molecular mechanism of the aging process. FIGURE 1 shows a summary of major pathways involved in the aging process. Absorption of UV radiation by chromophores in the skin results in formation of reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide. Normal oxidative metabolism (mitochondrial oxidative energy generation) also results in formation of excess ROS (20,21). ROS play a central role in intrinsic and extrinsic aging by increasing oxidative phosphorylation of cell surface receptors causing activation of one or more components of MAP kinase signaling pathways resulting in activation of transcription factors activator protein 1 (AP-1) and nuclear factor-kappa B (NF κ B) (22–25).
AP-1 stimulates transcription of matrix metalloproteinase (MMP) growth factor genes in fibroblast and keratinocytes, and inhibits type I procollagen gene expression in fibroblasts (10). Multiple studies have shown that activation of the MMP secretion as a result of intrinsic and extrinsic aging produces breakdown of dermal matrix (14,26,27). Different subtypes of MMP have different substrate proteins on which they act to produce a break in their primary sequence. MMP-1 (collagenase) produces cleavage at a single site in central triple helix of fibrillar type I and type III collagen. The cleaved subunits are further degraded by MMP-3 (stromelysine 1) and MMP-9 (gelatinase). Activity of MMP is decreased by binding with tissue inhibitors of metalloproteinase (TIMP). ROS inactivates TIMP thereby increasing MMP activity. AP-1 mediated reduction in synthesis of procollagen appears to result from two mechanisms, interference of AP-1 with type I and type III procollagen gene transcription and blocking the profibrotic effects of TGF β  by impairment of TGF β  type II receptor/ smad pathway (28). Activation of NF κ B stimulates transcriptions of proinflammatory cytokine genes including IL-1, TNF α , IL-6, and IL-8 (29). Inflammation resulting from these cytokines increases secretion of ROS and more cytokines further enhancing the effect of UV exposure. Inflammation causes protease

FIG. 2. Healing and remodeling of skin damaged by the effect of intrinsic aging, extrinsic aging, wound, or laser procedures.

mediated degradation of elastin and UV exposure causes formation of abnormal elastin by fibroblasts (19). UV light is also an inhibitor of leukocyte elastase thereby increasing accumulation of elastotic materials (30). The accumulation of elastotic materials is accompanied by degeneration of surrounding collagenous network (14). The overall effects of these interlinked biochemical activities is reduction of procollagen synthesis, increase of collagen degradation in the dermal extracellular matrix, and increase in irregular elastin deposition.


Growth factors as adjuncts to procedure:

Laser resurfacing rejuvenates skin primarily by producing controlled wounds to localized area,

FIG. 3. Visible reduction is periorbital wrinkles in 3 months with continued improvements for 6 months in a patient using TNS Recovery Complex twice daily for 60 days.

FIG. 4. Mean of facial wrinkle and texture scores as a function of time as assessed by investigators. The scores are baseline, after 30 days, and after 60 days of twice daily use of NeoCutis Bio-Restorative Skin Cream. (n = 18). (39)

which is followed by inflammation and healing resulting in stimulation of cytokine-mediated dermal collagen formation and structural remodeling of superficial dermis (45,46). Histologic studies have shown degrees of grenz zone collagen with laser rejuvenation similar to those with treatment
using topical retinoids, vitamin C and growth factors. For noninvasive, nonablative laser resurfacing, the post-treatment application of growth factors in a topical formulation may provide benefit in accelerated or improved wound healing. Laser resurfacing also alters the barrier properties

of skin and may allow greater penetration of growth factors immediately postprocedure. Therefore, combining growth factors with laser resurfacing should not only improve postprocedure recovery time but also provide a synergistic effect on skin rejuvenation. Growth factors are also useful in the preprocedure period to condition the skin and allow for a more robust rejuvenating response to laser resurfacing. 

Conclusion:

Aging of skin mediated by the effect of time and environmental factors shows a common molecular pathway involving reactive oxygen species. Aging results in loss of dermal collagen and accumulation of unorganized collagen and elastin in the dermis, resulting in formation of wrinkles, elastosis, and loss of skin tone. The process of reversing some of the effects of aging can be accelerated by use of topically applied growth factors that accelerate wound healing. Although it is unclear how large proteins such as growth factors actually penetrate the site of action, results of multiple clinical studies and continued marketplace success of products containing growth factors show the beneficial effects of these cosmeceutic products on reducing the signs and symptoms of facial skin aging. More double-blind and controlled studies are needed to confirm the preliminary clinical effects of growth factor products and more controls on product quality and stability need to be established. Synergistic effects of growth factors with other noninvasive procedures and other cosmeceutic products should also be evaluated further. 

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The Luxor: 30x54x38 Walk in Bathtub

All Fountain of Youth Bathrooms products are made with the highest-grade materials and are all factory tested before shipping. We also offer a lifetime warranty on every part of our products. Fountain of Youth Bathrooms is a name you can trust and depend on.

Hydrotherapy Jetted System

5 Piece Faucet Set

Built-In Grab Bar

Non-Slip Floor Surface

Cable Pop-Up Drain

6”Extension Panel

6 Leveling Legs

Stainless Steel Frame

17” Built -In Contoured Seat

18” easy access door

Lifetime Warranty.

http://www.clarosupply.com/The-Luxor-30x54x38-Walk-in-Bathtub-p/med0096.htm

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Michael Kors - Handbags and Watches

Michael Kors Ladies Watch IP Gold Stainless Steel - MK5780 - 100% Authentic.

Our Price: $159.00

Stainless steel case, IP gold, polished, set with stones

Stainless steel strap, IP gold, polished, folding clasp

Quartz movement, battery operated

Date display, 24 hour display

Dial set with stones

5 ATM Water Resistant

Case width ca. 38 mm

Michael Kors Fulton Mandarin Large Genuine Leather Shoulder Bag 100% Authentic.

Our Price: $269.99

Multifunction pockets, gold tone hardware.

pebbled leather, inside zip, cellphone and , zip-top closure.

Logo jacquard fabric lining.

outside front flap pocket with button-snap closure and back open slip pocket, logo details.

shoulder strap with with 9 in. drop, Approximate measurements: 14"(L)/ 12"(H)/ 6 1/2"(W)Product Dimensions: 14.6 x 14 x 4.9 inches; 2.2 pounds.

Shipping Weight: 2.2 pounds (View shipping rates and policies).